产品说明
一般描述
Isotretinoin is a vitamin A derivative, obtained from the isomerization of retinoic acid in the body. It is therapeutically used to treat severe recalcitrant nodular acne. It is also reported to exhibit anti-inflammatory and anti-tumor activities.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
应用
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Isotretinoin may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography.
生化/生理作用
13- 顺 -维甲酸 (RA) 具有抗炎和抗肿瘤操作。RA 的操作是通过 RAR-β 介导的和 RAR-α受体。RA 可减弱细胞因子刺激的小鼠系膜细胞 iNOS 的表达和活性。它诱导线粒体膜通透性转换，观察为肿胀和膜电位降低，并通过细胞凋亡途径刺激细胞色素 c 的释放牵连机制。这些活动被 EGTA 和环孢霉素 A 逆转。RA 也部分通过增加转录增加 MMP-1 蛋白表达。
分析说明
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
其他说明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
附注
To see an example of a Certificate of Analysis for this material enter LRAC0144 in the slot below. This is an example certificate only and may not be the lot that you receive.
基本信息
| 经验(实验)分子式 | C20H28O2 |
| 分子量 | 300.44 |
| EC 号 | 225-296-0 |
| MDL编号 | MFCD00079542 |
| PubChem化学物质编号 | 329823198 |
| NACRES | NA.24 |
产品性质
| 质量水平 | 300 |
| 等级 | certified reference material pharmaceutical secondary standard |
| CofA | current certificate can be downloaded |
| technique(s) | HPLC: suitable gas chromatography (GC): suitable |
| mp | 172-175 ℃ (lit.) |
| application(s) | pharmaceutical (small molecule) |
| 格式 | neat |
| 药典可追溯性 | traceable to PhEur I0800000 traceable to USP 1353500 |
| 储存温度 | -10 to -25℃ |
| SMILES string | [H]\C(C(O)=O)=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C |
| InChI | 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- |
| InChI key | SHGAZHPCJJPHSC-XFYACQKRSA-N |
| Gene Information | human ... RARA(5914), RARB(5915), RARG(5916) |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H315 - H319 - H335 - H360 |
| 预防措施声明 | P201 - P202 - P261 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
| 危险分类 | Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
SUPELCO
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