(5α,6α,7α,22<I>R</I>)-6,7-Epoxy-5,20,22-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone

产品名称：

32911-62-9
Withanolide A
Withaniol
(5α,6α,7α,22R)-6,7-Epoxy-5,20,22-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone

产品介绍：

产品说明

一般描述

Withanolide A is classified under the steroidal lactone group of bioactive compounds that are majorly found in Withania somnifera (L.).

应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Withanolide A may be used as an analytical standard for the determination of withanolide A in:

Mentat tablet, an Indian herbal medicine by UHPLC coupled to tandem mass spectrometry (MS/MS) operating with ESI, along with multivariate analysis.
Withania somnifera by ultra-high performance liquid chromatography-hybrid triple quadrupole linear ion trap mass spectrometer (UHPLC-QqQ LIT-MS) equipped with electrospray ionization (ESI) source and MRM detection, along with multivariate analysis as well as HPLC combined with diode array detector (DAD).
Withania coagulans by LC-QqQ-ESI-MS/MS.

生化/生理作用

C₂₈-steroidal lactone that can induce nerve development and improve nervous system function. Potential therapeutic for neurologic disorders like Alzheimer′s and Parkinson′s disease. In primary rat cortical neurons, withanolide A significantly up-regulated IDE levels, a prominent enzyme involved in degrading amyloid β protein, which may help to clear excess amyloid β protein from an Alzheimer′s-inflicted brain.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

基本信息

经验(实验)分子式	C₂₈H₃₈O₆
分子量	470.60
MDL编号	MFCD07779143
PubChem化学物质编号	329765849
NACRES	NA.24

产品性质

等级	analytical standard
质量水平	100
测定	≥95.0% (HPLC)
保质期	limited shelf life, expiry date on the label
technique(s)	HPLC: suitable gas chromatography (GC): suitable
application(s)	food and beverages
格式	neat
SMILES string	CC1=C(C)C(=O)O[C@H](C1)[C@](C)(O)[C@H]2CC[C@H]3[C@H]4[C@H](CC[C@]23C)[C@@]5(C)C(=O)C=CC[C@]5(O)[C@H]6O[C@@H]46
InChI	1S/C28H38O6/c1-14-13-20(33-24(30)15(14)2)27(5,31)18-9-8-16-21-17(10-12-25(16,18)3)26(4)19(29)7-6-11-28(26,32)23-22(21)34-23/h6-7,16-18,20-23,31-32H,8-13H2,1-5H3/t16-,17-,18-,20+,21-,22-,23-,25-,26-,27+,28-/m0/s1
InChI key	DXWHOKCXBGLTMQ-SFQAJKIESA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable