4-(1-[4-(二甲基氨基乙氧基)苯基]-2-苯基-1-丁烯)苯酚

产品名称：

68392-35-8
4-Hydroxytamoxifen
4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol
cis/trans-4-Hydroxytamoxifen
4-OHT
4-羟基他莫西芬
顺/反-4-羟基三苯氧胺
4-(1-[4-(二甲基氨基乙氧基)苯基]-2-苯基-1-丁烯)苯酚

产品介绍：

产品说明

一般描述

4-Hydroxytamoxifen is a first generation, selective estrogen receptor modulator (SERM) that functions as an antagonist in breast cancer cells but can display estrogen-like activities in the uterus and bone.

应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
4-Hydroxytamoxifen may be used as a reference standard in the determination of 4-hydroxythmoxifen in plasma samples using high-performance liquid chromatography with fluorescence detection (HPLC).

生化/生理作用

化疗药物他莫西芬的代谢物，表现出比原药更强效的雌激素激动剂/拮抗剂活性。还是脂质过氧化的活性膜内抑制剂。

基本信息

经验(实验)分子式	C₂₆H₂₉NO₂
分子量	387.51
NACRES	NA.24

产品性质

等级	analytical standard
质量水平	100
测定	≥97.5% (HPLC)
保质期	limited shelf life, expiry date on the label
technique(s)	HPLC: suitable gas chromatography (GC): suitable
杂质	≤5.0% water
application(s)	forensics and toxicology pharmaceutical (small molecule)
格式	neat
SMILES string	CC\C(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3.CC\C(c4ccccc4)=C(\c5ccc(O)cc5)c6ccc(OCCN(C)C)cc6
InChI	1S/2C26H29NO2/c21-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h25-17,28H,4,18-19H2,1-3H3/b26-25+;26-25-
InChI key	ZJLDABGSDWXVGE-BDSXMVAQSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 + H312 + H332 - H361
预防措施声明	P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
危险分类	Acute Tox. 4 Oral - Repr. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable