产品说明
一般描述
Retigabine is an antiepileptic drug, which activates neuronal KCNQ-type K+ channels by inducing a large hyperpolarizing shift of steady-state activation.
应用
Retigabine may be used as a reference standard in the determination of retigabine in biological matrices using high-performance liquid chromatography coupled with tandem mass spectrometry with positive ion atmospheric pressure chemical ionization (HPLC-APCI-MS/MS).
生化/生理作用
Retigabine (Ezogabine) is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity.
基本信息
| 经验(实验)分子式 | C16H18FN3O2 |
| 分子量 | 303.33 |
| Beilstein | 8072099 |
| MDL编号 | MFCD04307735 |
| PubChem化学物质编号 | 329769861 |
| NACRES | NA.24 |
产品性质
| 质量水平 | 100 |
| 等级 | analytical standard |
| 测定 | ≥98.0% (HPLC) |
| 保质期 | limited shelf life, expiry date on the label |
| drug control | USDEA Schedule IV |
| technique(s) | HPLC: suitable gas chromatography (GC): suitable |
| 杂质 | ≤1.0% water (calc. from elemental analysis) |
| application(s) | forensics and toxicology veterinary |
| 格式 | neat |
| 储存温度 | 2-8℃ |
| SMILES string | FC1=CC=C(CNC2=CC(N)=C(NC(OCC)=O)C=C2)C=C1 |
| InChI | 1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21) |
| InChI key | PCOBBVZJEWWZFR-UHFFFAOYSA-N |
| Gene Information | human ... KCNQ1(3784), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479) |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H301 + H331 - H410 |
| 预防措施声明 | P261 - P264 - P270 - P273 - P301 + P310 - P304 + P340 + P311 |
| 危险分类 | Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
SUPELCO
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